Development of MicroRNAs as potential therapeutics against cancer
Document Type
Article
Publication Date
7-1-2020
Abstract
MicroRNAs (miRNAs) are small noncoding RNAs that function at the posttranscriptional level in the cellular regulation process. miRNA expression exerts vital effects on cell growth such as cell proliferation and survival. In cancers, miRNAs have been shown to initiate carcinogenesis, where overexpression of oncogenic miRNAs (oncomiRs) or reduced expression of tumor suppressor miRNAs has been reported. In this review, we discuss the involvement of miRNAs in tumorigenesis, the role of synthetic miRNAs as either mimics or antagomirs to overcome cancer growth, miRNA delivery, and approaches to enhance their therapeutic potentials.
Keywords
Cancer gene therapy, Carcinogenesis, Clinical trial (topic), Gene control, Gene function, Gene targeting, Human, Malignant neoplasm, Molecular evolution
Divisions
biomedsc
Funders
Centre for Virus and Vaccine Research,Sunway University Research Centre
Publication Title
Journal of Oncology
Volume
2020
Publisher
Hindawi Ltd
Publisher Location
ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND