Microwave synthesis of hydroxyapatite encumbered with ascorbic acid intended for drug leaching studies
Document Type
Article
Publication Date
1-1-2020
Abstract
The characteristics properties of hydroxyapatite (HAP, Ca10 (PO4)6(OH) 2) namely, bioactivity, biocompatibility, osteoconductive and adsorption capacity can be tailored over wide assortments by governing the particle composition, particle dimensions, and structure. Pure hydroxyapatite (HAP) nanoparticles were synthesized by a simple straightforward approach using microwave irradiation method. The prepared HAP samples were studied for phase purity using X-ray diffractometer (XRD); functional group analysis using Fourier transform Infrared (FTIR) spectroscopy. Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM) was used to examine the assembling of the HAP particles. These outcomes validate that shorter rod–like HAP particles can be organized by microwave irradiation technique. The synthesized HAP samples were loaded with ascorbic acid to analyze it’s in vitro drug release studies and its biocompatibility was confirmed by means of MTT assay using Saos-2 cell lines (Human Osteosarcoma Cell Line). © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Keywords
HAP, Microwave method, nanorods, ascorbic acid, MTT assay
Divisions
nanotechnology
Publication Title
Materials Research Innovations
Volume
24
Issue
3
Publisher
Taylor & Francis