Benzimidazolium-acridine-based silver N-heterocyclic carbene complexes as potential anti-bacterial and anti-cancer drug
Document Type
Article
Publication Date
1-1-2020
Abstract
A series of N-alkylated benzimidazolium salts based on 9-substituted acridine has been synthesized and subsequently converted into the corresponding Ag(I) carbene complexes. The compounds were characterized by IR, 1H and 13C NMR spectroscopy. Identity and purity were confirmed by HRMS and elemental analysis, respectively. Both, ligands and complexes, were evaluated on their antibacterial and anticancer potential. All complexes exhibited higher activity against both Gram positive and Gram negative bacterial strains than the corresponding ligands. Human cell line experiments indicated low in-vitro cytotoxicity, while some of the complexes showed promising activity against breast cancer cells. © 2020 Elsevier B.V.
Keywords
9-Aminoacridine, Ag(I)-benzimidazolium, Breast cancer (MCF-7), Gram positive, Gram negative
Divisions
fac_med,CHEMISTRY
Funders
University of Malaya under research grant PG108–2016A
Publication Title
Inorganica Chimica Acta
Volume
504
Publisher
Elsevier