Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana
Document Type
Article
Publication Date
1-1-2020
Abstract
One new aporphine named tavoyanine A (1), along with four known aporphines laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), and one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe tavoyana (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chromatographic techniques, and the structural elucidation was performed via spectral methods. This paper also reports the antiplasmodial activity of roemerine (3), laurolitsine (4), boldine (5), and sebiferine (6). The results showed that 3–6 have a potent inhibitory activity against the growth of Plasmodium falciparum 3D7 clone, with IC50 values of 0.89, 1.49, 1.65, and 2.76 µg/ml, respectively. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Keywords
Phoebe tavoyana, Lauraceae, aporphine alkaloid, morphinandienone, antiplasmodial, Plasmodium falciparum
Divisions
chemistry,CHEMISTRY
Funders
PPP Grant (PV091/ 2011B) and BKP Grant (BKP069-2016) from University of Malaya
Publication Title
Journal of Asian Natural Products Research
Volume
22
Issue
1
Publisher
Taylor & Francis