α-glucosidase inhibitors isolated from Mimosa pudica L.
Document Type
Article
Publication Date
1-1-2019
Abstract
The aim of the study was to isolate digestive enzymes inhibitors from Mimosa pudica through a bioassay-guided fractionation approach. Repeated silica gel and sephadex LH 20 column chromatographies of bioactive fractions afforded stigmasterol, quercetin and avicularin as digestive enzymes inhibitors whose IC50 values as compared to acarbose (351.02 ± 1.46 μg mL−1) were found to be as 91.08 ± 1.54, 75.16 ± 0.92 and 481.7 ± 0.703 μg mL−1, respectively. In conclusion, M. pudica could be a good and safe source of digestive enzymes inhibitors for the management of diabetes in future. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Keywords
Mimosa pudica, Fabaceae, α-glucosidase inhibitors
Divisions
nanotechnology
Funders
Research initiative grant scheme [RIGS16-397-0561 and RIGS 16-294-0458] of International Islamic University Malaysia,International Scientific Partnership Program ISPP at King Saud University, Riyadh, Saudi Arabia: ISPP# 0026
Publication Title
Natural Product Research
Volume
33
Issue
10
Publisher
Taylor & Francis