Two New isoquinoline alkaloids from the bark of Alphonsea cylindrica King and their antioxidant activity
Document Type
Article
Publication Date
1-1-2019
Abstract
Two new isoquinoline alkaloids, iraqiine (1) and kareemine (2), along with five known alkaloids, muniranine (3), kinabaline (4), O-methylmoschatoline (5), atherospermidine (6) and N-methylouregidione (7), were purified from the dichloromethane crude extract of Alphonsea cylindrica bark. The structures of these compounds were elucidated through extensive 1D and 2D NMR, IR and LC–MS studies and comparison with previously reported data. Compounds (1–5 and 7) were tested for their antioxidant activity using in vitro DPPH radical scavenging assay, and 1, 3 and 4 showed the highest antioxidant activities with IC50 values of 48.77 ± 1.01, 44.51 ± 1.12 and 64.28 ± 0.93 μg/ml, respectively.
Keywords
Alphonsea cylindrical, Isoquinoline, Oxoaporphine, Bisbenzylisoquinoline, DPPH
Divisions
CHEMISTRY
Funders
Universiti Pendidikan Sultan Idris Special Grant Scheme (Fundamental) 2017-0331-101-01
Publication Title
Phytochemistry Letters
Volume
29
Publisher
Elsevier