Oncogenic Signaling in Tumorigenesis and Applications of siRNA Nanotherapeutics in Breast Cancer
Document Type
Article
Publication Date
1-1-2019
Abstract
Overexpression of oncogenes and cross-talks of the oncoproteins-regulated signaling cascades with other intracellular pathways in breast cancer could lead to massive abnormal signaling with the consequence of tumorigenesis. The ability to identify the genes having vital roles in cancer development would give a promising therapeutics strategy in combating the disease. Genetic manipulations through siRNAs targeting the complementary sequence of the oncogenic mRNA in breast cancer is one of the promising approaches that can be harnessed to develop more efficient treatments for breast cancer. In this review, we highlighted the effects of major signaling pathways stimulated by oncogene products on breast tumorigenesis and discussed the potential therapeutic strategies for targeted delivery of siRNAs with nanoparticles in suppressing the stimulated signaling pathways. © 2019, MDPI AG. All rights reserved.
Keywords
breast cancer, siRNA, cell signaling, active targeting, passive targeting, EPR effect, oncogenes, nanoparticles, nanomedicine
Divisions
fac_med
Funders
Sunway University Research Centre Grant (2018)
Publication Title
Cancers
Volume
11
Issue
5
Publisher
MDPI