Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan
Document Type
Article
Publication Date
1-1-2019
Abstract
Gel filtration chromatography and gel electrophoresis revealed minimal protein degradation in lyophilized antivenoms which were 2-year expired (Hemato Polyvalent, Neuro Polyvalent; Thailand) and 18-year expired (Hemato Bivalent, Neuro Bivalent; Taiwan). All expired antivenoms retained immunological binding activity, and were able to neutralize the hemotoxic or neurotoxic as well as lethal effects of the homologous snake venoms. The findings show that antivenoms under proper storage conditions may remain relatively stable beyond the indicated shelf life. © 2019 Elsevier Ltd
Keywords
Antivenins, Chromatography, Gel, Drug Stability, Electrophoresis, Polyacrylamide Gel, Neutralization Tests, Snake Venoms, Taiwan, Thailand
Divisions
fac_med
Funders
University of Malaya for the provision of research facilities and funding (Grants no. RG352-15AFR and BKS003-2017)
Publication Title
Toxicon
Volume
160
Publisher
Elsevier