Dengue protease inhibition activity of selected malaysian medicinal herbs
Document Type
Article
Publication Date
1-1-2019
Abstract
Dengue fever is one of major health problem around the world including Malaysia. It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, or DENV-4). In this study, a screening exercise of various Malaysian medicinal plants showed that the extracts of Lawsonia inermis, Dryobalanops aromatica, Punica granatum, Zizyphus jujuba Lam. and Zingiber zerumbet exhibited potent inhibitory activity against NS2B-NS3 serine protease. The methanol extracts of Dryobalanops aromatica showed inhibition of 99.70 % at concentration of 200 µg/mL with IC50 value of 0.30 ± 0.16 µg/mL. © 2019, Malaysian Society for Parasitology. All rights reserved.
Keywords
Culicidae, Aedes, C quinquefasciatus
Divisions
Hadith,chemistry,fac_med,CHEMISTRY
Funders
Ministry of Higher Education through the Trans Disciplinary Research Grant Scheme (TR001B-2014A),USIM C (PPP/ UCG-0116/FPQS/30/14316),Postgraduate Research Grant, PPP (PG101-2016A)
Publication Title
Tropical Biomedicine
Volume
36
Issue
2
Publisher
Malaysian Society of Parasitology and Tropical Medicine