Baicalein and baicalin as Zika virus inhibitors
Document Type
Article
Publication Date
1-1-2019
Abstract
At present, there is no effective antiviral agent for Zika virus (ZIKV), an arbovirus that is known for its teratogenic effects on newborns. Baicalein and baicalin were found to be capable of downregulating ZIKV replication up to 10 hours postinfection, while prophylactic effects were evident in pre-treated cells. Baicalein exhibited its highest potency during intracellular ZIKV replication, whereas baicalin was most effective against virus entry. Our in silico interaction assays predicted that both compounds exhibited the strongest binding affinities towards ZIKV NS5, while the virus envelope glycoprotein was the least likely target protein. These findings serve as a crucial platform for further in-depth studies to decipher the underlying anti-ZIKV mechanism(s) of each compound. © 2018, Springer-Verlag GmbH Austria, part of Springer Nature.
Keywords
Antiviral Agents, Flavanones, Flavonoids, Humans, Viral Envelope Proteins, Virus Internalization, Virus Replication, Zika Virus, Zika Virus Infection
Divisions
tidrec
Funders
University of Malaya via a Postgraduate Research Grant (PPP) (PG151-2016A)
Publication Title
Archives of Virology
Volume
164
Issue
2
Publisher
Springer Verlag (Germany)