Thraatchathi chooranam, protects cardiomyocytes against oxidative stress
Document Type
Article
Publication Date
1-1-2018
Abstract
Thraatchathi Chooranam (TC), is a polyphenol-rich Indian traditional medicine. Present study was undertaken to investigate the effects of TC against H2O2 induced oxidative stress and apoptotic damage in H9C2 cardiomyocytes. Cell viability assay indicated relative safety (IC50= 488.10±12.04 mg/ml) of TC. Pretreatment of cells with TC upregulated antiapoptotic Bcl2, and anti-oxidants TRX1 and TRXR and downregulated Bax and HIF-α and inflammatory genes iNOS and TNF-α. Together, these findings show that TC has both anti-oxidant and anti-apoptotic properties. Further studies may be considered to identify the bioactive principle(s) and precise mechanisms of action of TC.
Keywords
Thraatchathi Chooranam, Polyphenols, Cardiovascular Disease, Hydrogen peroxide, Antiapoptotic, Oxidative stress, Cytokine
Divisions
fac_med
Funders
University of Malaya (Reference number: UM.C/625/1/HIR/MOHE/CHAN/03; account number: A000003-50001)
Publication Title
Frontiers in Bioscience, Elite
Volume
10
Issue
3
Publisher
Frontiers in Bioscience