Synthesis and characterization of some novel 4-arylglyoxal-chromene derivatives in the presence of a polymeric catalyst and biological evaluation against Escherichia coli

Authors

Nader Ghaffari KhalighFollow

Document Type

Article

Publication Date

1-1-2018

Abstract

A poly(N-vinylimidazole)-catalyzed one-pot multicomponent reaction for the synthesis of 2-amino-4H-benzo[g]chromenes containing acyl group on the 4H-chromene ring has been developed. The products were obtained in generally good to excellent yields in the presence of low loading of poly(N-vinylimidazole) as a reusable basic catalyst via this synthetic strategy. Importantly, the catalyst has the unique ability of being easily separated and recycled. The products were screened for their antibacterial activity against Escherichia coli. The results of antibacterial studies showed that three 4-aroylchromene derivatives completely inhibited E. coli at 32 mg cm−3, whereas other derivatives were either moderately active or inactive up to 64 mg cm−3. Highest antimicrobial activity was observed when the phenylglyoxal hydrate was substituted with fluoro, nitro, and methoxy groups at para position.

Keywords

4-Aroylchromenes, Antibacterial, Escherichia coli, Heterogeneous catalysis, One-pot three-component reaction

Divisions

nanotechnology

Publication Title

Monatshefte fur Chemie - Chemical Monthly

Volume

149

Issue

1

Publisher

Springer Verlag