Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions

Document Type

Article

Publication Date

1-1-2018

Abstract

A mild and efficient protocol for the one-pot synthesis of 4-amidocinnolines was developed using saccharin as a cheap and eco-friendly organocatalyst and t-butyl nitrite as a metal-free diazotization reagent. The current method has advantages such as cost effectiveness, use of the biodegradable reagents, simple experimental procedure; afford the quantitative yield of the desired products, metal- and halogen-free as well as environmentally benign conditions.

Keywords

Cinnoline, Metal-free condition, One-pot synthesis, Saccharin, t-Butyl nitrite

Divisions

nanotechnology

Publication Title

Monatshefte fur Chemie - Chemical Monthly

Volume

149

Issue

6

Publisher

Springer Verlag

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