Parametric optimization of polycaprolactone synthesis catalysed by Candida antarctica lipase B using response surface methodology
Document Type
Article
Publication Date
1-1-2018
Abstract
A statistical approach with D-optimal design was used to optimize the process parameters for polycaprolactone (PCL) synthesis. The variables selected were temperature (50°C-110°C), time (1-7 h), mixing speed (50-500 rpm) and monomer/solvent ratio (1:1-1:6). Molecular weight was chosen as response and was determined using matrix-assisted laser desorption/ionization time of flight (MALDI TOF). Using the D-optimal method in design of experiments, the interactions between parameters and responses were analysed and validated. The results show a good agreement with a minimum error between the actual and predicted values.
Keywords
Candida Antarctica lipase B, D-optimal method, design of experiment, enzymatic polymerization, optimization, polycaprolactone
Divisions
fac_eng
Publication Title
Biopolymers
Volume
109
Issue
12
Publisher
Wiley