Genetic variants of Orientia tsutsugamushi identified from scrub typhus cases in Malaysia
Document Type
Article
Publication Date
1-1-2016
Abstract
We report herein the clinical presentation and diagnosis of scrub typhus in three patients attending a teaching hospital in Malaysia. Three genetic variants belonged to the Karp and Gilliam strains of O. tsutsugamushi were amplified from the acute blood samples of the patients by a nested polymerase chain reaction assay. The circulation of different genetic variants of O. tsutsugamushi strains might complicate the presentation and severity of scrub typhus. Loop-PCR is a promising diagnostic tool for rapid diagnosis of scrub typhus.
Keywords
Genetic variants, Orientia tsutsugamushi, Scrub typhus cases, Malaysia
Divisions
fac_med
Funders
University of Malaya: Grants HIR/E000013-20001 (subprogramme 4), Postgraduate Research Grant (PPP) PG058-2013B and RP013A/2012
Publication Title
Tropical Biomedicine
Volume
33
Issue
1
Publisher
Malaysian Society for Parasitology