Green synthesis of anisotropic zinc oxide nanoparticles with antibacterial and cytofriendly properties
Document Type
Article
Publication Date
1-1-2018
Abstract
Zinc oxide nanoparticles (ZnONPs) exhibit abundant biomedical applications. Anisotropic ZnONPs with a defined shape and size were synthesized using Bacillus megaterium (NCIM 2326) cell free extract as a bio-reductant. The study investigated the multidimensional effect of ZnONPs on Helicobacter pylori strains and assessed its biosafety in normal human mesenchymal stem cells (hMSc). The highly stable ZnONPs were produced using B. megaterium and Zinc nitrate as a precursor. The phase of ZnONPs formation and structural characterization were performed by UV- visible (UV-Vis), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and Field Emission Scanning electron microscopy (FESEM) analysis. Furthermore, the ZnONPs exhibited higher biocompatibility against human mesenchymal stem cells (hMSC) and proved to be potentially safe in mammalian cells. Corroborating the current investigation, we described the anti-H. Pylori dosage of ZnONPs was safe to hMSC and could efficiently use as nano-antibiotic.
Keywords
Bacillus megaterium, Nanoparticles, Antibacterial mechanism, Helicobacter pylori, Cytotoxicity
Divisions
fac_med
Funders
Deanship of Scientific Research at King Saud University for funding this work through research group No (RG-1438-078)
Publication Title
Microbial Pathogenesis
Volume
115
Publisher
Elsevier