Facile Intramolecular Cyclization of N -(2-Hydroxybenzoyl)hydrazones to N ,N′ -Diacetyl Benzo-1,3,4-oxadiazepine Derivatives

Document Type

Article

Publication Date

1-1-2018

Abstract

A facile synthesis of seven-membered benzo-1,3,4-oxadiazepines through one-step intramolecular cyclization of N-(2-hydroxybenzoyl)hydrazones has been established. The catalytic and substituent effects on the reactivity of this intramolecular cyclization were investigated. Through this strategy, a series of benzo-1,3,4-oxadiazepine derivatives were prepared (with yields up to 83 %).

Keywords

benzo-1, 3, 4-oxadiazepine, Brønsted acids, cyclization, hydrazones, substituent effects

Divisions

CHEMISTRY

Funders

Ministry of Education Malaysia (FRGS FP010-2014B)

Publication Title

Asian Journal of Organic Chemistry

Volume

7

Issue

4

Publisher

Wiley-VCH Verlag

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