Fabrication of platinum nitrogen-doped graphene nanocomposite modified electrode for the electrochemical detection of acetaminophen
Document Type
Article
Publication Date
1-1-2018
Abstract
An electrochemical sensor for the determination of acetaminophen (AC) was fabricated on glassy carbon electrode (GCE) modified with platinum nitrogen-doped graphene (Pt/NGr) nanocomposite. Electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and square-wave voltammetry (SWV) were performed to investigate the electrochemical behaviour of AC. From the electrochemical results, the synergy between platinum nanoparticles and nitrogen-doped graphene improved the interfacial electron transfer process, thus exhibited a higher catalytic performance towards the electrochemical oxidation of AC. A linear range between 0.05–90 μmol L−1 for the determination of AC was achieved with a limit of detection of 0.008 μmol L−1. The prepared sensor demonstrated acceptable reproducibility, stability and good selectivity in the presence of interferences such as ascorbic acid, p-aminophenol and dopamine. In addition, this method showed satisfactory results in commercial tablets.
Keywords
Acetaminophen, Electrochemical sensor, Graphene, Platinum nanoparticles
Divisions
CHEMISTRY,PHYSICS,nanotechnology
Funders
University of Malaya under Postgraduate Research Grant (PPP) PG093-2015B and FP039 2106
Publication Title
Sensors and Actuators B: Chemical
Volume
266
Publisher
Elsevier