Enhanced amperometric detection of paracetamol by immobilized cobalt ion on functionalized MWCNTs - Chitosan thin film
Document Type
Article
Publication Date
1-1-2018
Abstract
In the present study, a nanocomposite of f-MWCNTs-chitosan-Co was prepared by the immobilization of Co(II) on f-MWCNTs-chitosan by a self-assembly method and used for the quantitative determination of paracetamol (PR). The composite was characterized by field emission scanning electron microscopy (FESEM) and energy dispersive x-ray analysis (EDX). The electroactivity of cobalt immobilized on f-MWCNTs-chitosan was assessed during the electro-oxidation of paracetamol. The prepared GCE modified f-MWCNTs/CTS-Co showed strong electrocatalytic activity towards the oxidation of PR. The electrochemical performances were investigated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV). Under favorable experimental conditions, differential pulse voltammetry showed a linear dynamic range between 0.1 and 400 μmol L−1 with a detection limit of 0.01 μmol L−1 for the PR solution. The fabricated sensor exhibited significant selectivity towards PR detection. The fabricated sensor was successfully applied for the determination of PR in commercial tablets and human serum sample.
Keywords
Paracetamol, Electrochemical sensor, f-Multi-wall carbon nanotube, Chitosan, Cobalt
Divisions
CHEMISTRY,nanotechnology
Funders
University Malaya, Ministry of Higher Education (MOHE) and University of Malaya Centre for Ionic Liquids (UMCiL) through grant numbers of FP039 2016A and RH 2017
Publication Title
Analytical Biochemistry
Volume
551
Publisher
Elsevier