A rare case of solitary unifocal Langerhans cell histiocytosis with orbital extension: Diagnostic dilemma
Document Type
Article
Publication Date
1-1-2018
Abstract
Langerhans cell histiocytosis (LCH) is rarely encountered in ophthalmology practice. It is a spectrum of disorder characterized by accumulation of histiocytes in various tissues. Diagnosis is challenging as it may simulate periorbital hematoma, rhabdomyosarcoma, and neuroblastoma. We report a case of unifocal LCH with orbital extension. Diagnosis was obtained from incisional biopsy, and histopathological examination showed numerous histiocytes with eosinophilic infiltrations. The presence of Langerhans cells was confirmed by the presence of protein S-100, CD1a, and/or Langerin (CD207). Treatment depends on the degree of organ involvement. She responded well to cytotoxic drugs and steroids. This emphasized that prompt tissue diagnosis is crucial for early management.
Keywords
Langerhans cell histiocytosis, orbit, uniforcal
Divisions
fac_med
Publication Title
Oman Journal of Ophthalmology
Volume
11
Issue
3
Publisher
Medknow Publications