Tailoring the morphological features of hydrothermally synthesized mesoporous hydroxyapatite using polyphenols and phosphate sources
Document Type
Article
Publication Date
1-1-2017
Abstract
Hydroxyapatite (HA) is a well-known material for biomedical applications and its performance depends greatly on its morphological features. Therefore, preparation of mesoporous HA with high surface area and adsorption capacity is highly deserved. In this research, a hydrothermal approach to synthesize mesoporous HA without post-processing calcination step is presented. The possibility using different polyphenols to generate mesoporous HA as well as using different phosphate sources to tailor the morphological features of HA is investigated. The as-prepared mesoporous HA particles are characterized by XRD, FTIR, SEM, TEM, BET, and zeta potential. Besides, the impacts of HA morphological features on model drug Dox are also studied. It is expected the strong interaction between –OH of polyphenols and Ca2+ makes polyphenols molecules occupy the inner sites of growing HA particles. After the removal of polyphenols by hydrothermal treatment and ethanol extraction, the occupied sites are transformed into mesopores. The typical mesoporous HA generated in present work has a rod-like morphology with BET specific surface area of 106.6 m2/g and an average pore size of 14.4 nm.
Keywords
A. Powders: chemical preparation, B. Porosity, D. Apatite, E. Biomedical applications, Polyphenols
Divisions
fac_med
Funders
Changzhou Sci & Tech Program (No. CJ20160040),The Natural Science Foundation of Jiangsu Province Research of China (No. BK20151181),High-Level Medical Talents Training Project of Changzhou (No. 2016CZLJ004),The Municipal Social Development Project of the Changzhou (No. CJ20160029),National Natural Science Foundation of China (No. 81622032),National Natural Science Foundation of China (No. 51672184)
Publication Title
Ceramics International
Volume
43
Issue
15
Publisher
Elsevier