Development of poly (1, 8-octanediol citrate)/chitosan blend films for tissue engineering applications
Document Type
Article
Publication Date
1-1-2017
Abstract
Blends of poly (1, 8-octanediol citrate) (POC) and chitosan (CS) were prepared through solution casting technique. Films with different component fractions (POC/CS: 100/0, 90/10, 80/20, 70/30, 60/40, and 0/100) were successfully prepared and characterized for their mechanical, thermal, structural and morphological properties as well as biocompatibility. The incorporation of CS to POC significantly increased tensile strength and elastic modulus and presented limited influences on pH variation which is important to the biocompatibility of biomaterial implants. The assessment of surface topography indicated that blending could enhance and control the surface roughness of the pure films. POC/CS blends well-supported human dermal fibroblast cells attachment and proliferation, and thus can be used for a range of tissue engineering applications.
Keywords
Poly (1, 8-octanediol citrate), Chitosan, Blend films, Biocompatible, Tissue engineering
Divisions
fac_eng,fac_med
Funders
University of Malaya Research Grant (UMRG, RP040C-15HTM),Postgraduate Research Grant (PPP: PG077-2015B)
Publication Title
Carbohydrate Polymers
Volume
175
Publisher
Elsevier