Document Type
Article
Publication Date
1-1-2011
Abstract
Clerodendron capitatum (Willd) (family: verbenaceae) is locally named as Gung and used traditionally to treat erectile dysfunction.Therefore, the current study was designed to investigate the erectogenic properties of C. capitatum. The relaxation effect of this plant was tested on phenylephrine precontracted rabbit corpus cavernosum smooth muscle (CCSM). The effects of C. capitatum were also examined on isolated Guinea pig atria alone, in the presence of calcium chloride (Ca 2+ channel blocker), atropine(cholinergic blocker), and glibenclamide (ATP-sensitive K +channel blocker). These effects were confirmed on isolated rabbit aortic strips. The extract, when tested colorimetrically for its inhibitory activities on phosphordiesterase-5 (PDE-5) in vitro towards pnitrophenyl phenyl phosphate (PNPPP), was observed to induce significant dose-dependent inhibition of PDE-5, with an ID50 of 0.161 mg/ml (P < .05). In conclusion, our results suggest that C. capitatum possesses a relaxant effect on CCSM, which is attributable to the inhibition of PDE-5, but not mediated by the release calcium, activation of adrenergic or cholinergic receptors, or the activation of potassium channels.
Keywords
Clerodendron Capitatum
Divisions
fac_med
Publication Title
Evidence-Based Complementary and Alternative Medicine
Volume
2012
Publisher
Hindawi
Additional Information
Correspondence should be addressed to Siddig Ibrahim Abdelwahab, siddigroa@yahoo.com