Document Type
Article
Publication Date
1-1-2015
Abstract
The most common form of malignant renal neoplasms is renal cell carcinoma (RCC), which is classified into several different subtypes based on the histomorphological features. However, overlaps in these characteristics may present difficulties in the accurate diagnosis of these subtypes, which have different clinical outcomes. Genomic and molecular studies have revealed unique genetic aberrations in each subtype. Knowledge of these genetic changes in hereditary and sporadic renal neoplasms has given an insight into the various proteins and signalling pathways involved in tumour formation and progression. In this review, the genetic aberrations characteristic to each renal neoplasm subtype are evaluated along with the associated protein products and affected pathways. The potential applications of these genetic aberrations and proteins as diagnostic tools, prognostic markers, or therapeutic targets are also assessed.
Keywords
Genetic, Chromosomal Aberrations, Clinical Significance, Renal Neoplasms
Divisions
fac_med
Funders
University Malaya Research Fund Assistance BK024-2013
Publication Title
BioMed Research International
Volume
2015
Publisher
Hindawi Publishing Corporation