Synthesis, characterization and biological studies of S-4-methylbenzyl-β-N-(2-furylmethylene)dithiocarbazate (S4MFuH) its Zn2+, Cu2+, Cd2+ and Ni2+ complexes
Document Type
Article
Publication Date
1-1-2015
Abstract
S-4-methylbenzyl-β-N-(2-furylmethylene)dithiocarbazate (S4MFuH, 1) derived from the condensation reaction of furaldehyde (Fu) with S-4-methylbenzyldithiocarbazate (S4MBDTC) has been complexed with transition metal acetates to give Zn(S4MFu)2 (2), Cd(S4MFu)2 (3), Cu(S4MFu)2 (4) and Ni(S4MFu)2 (5). It is evident from the shift in ν(C=N) and ν(N-N) in the IR spectra of the complexes that deprotonated 1 acts as a bidentate ligand coordinating through the azomethine nitrogen and thiolato sulfur atoms. This was confirmed by single crystal X-ray diffractometry. The U-shaped dithiocarbazate 1 exists in the E configuration with the thione bond anti to the azo bond. A change in conformation is noted in the transition metal complexes resulting from deprotonation and N-S-chelation. 2 and 3 display a distorted tetrahedral geometry with the major cause of the distortion being two close intramolecular M...O interactions. Binding interaction studies with calf thymus DNA demonstrated that 4 also had the strongest DNA binding affinity (Kb = 2.85 × 104 M-1) among all compounds prepared in this work. The Cu(II) complex, 4, was also moderately active against estrogen receptor-positive breast cancer cells, MCF-7 (IC50 = 3.02 μM) while the remainder were inactive against MCF-7 and all showed no activity towards receptor negative breast cancer cells, MDA-MB-231.
Keywords
S-4-methylbenzyldithiocarbazate, Furaldehyde, Transition metal complexes, NS bidentate Schiff base, Single crystal X-ray diffraction Cytotoxic activity
Divisions
CHEMISTRY
Funders
Universiti Putra Malaysia (UPM) and the Malaysian Government under the Research University Grant Scheme (RUGS No. 9419400),Malaysian Fundamental Research Grant Scheme (FRGS No. 01-02-13-1344FR),Science Fund under the Ministry of Science, Technology and Innovation (MOSTI) (06-01-04-SF1810),High Impact Research Ministry of Education Grant UM.C/625/1/HIR/MoE/SC/12 from the Ministry of Higher Education, Malaysia and the University of Malaya
Publication Title
Inorganica Chimica Acta
Volume
438
Publisher
Elsevier