Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells
Document Type
Article
Publication Date
1-1-2015
Abstract
Numerous documented ethnopharmacological properties have been associated with Swietenia macrophylla (Meliaceae), with its seed extract reported to display anti-hypoglycemic activities in diabetic rats. In the present study, three compounds isolated from the seeds of S. macrophylla were tested on a modified ELISA binding assay and showed to possess PPAR ligand activity. They were corresponded to PPAR-mediated cellular response, stimulated adipocyte differentiation but produced lower amount of fat droplets compared to a conventional anti-diabetic agent, rosiglitazone. The up-regulation of adipocytes was followed by increased adipocyte-related gene expressions such as adiponectin, adipsin, and PPAR. The S. macrophylla compounds also promoted cellular glucose uptake via the translocation of GLUT4 glucose transporter.
Keywords
Swietenia macrophylla, PPAR gamma ligand, GLUT4 translocation, Glucose uptake
Publication Title
Molecules
Volume
20
Issue
12