Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng

Document Type

Article

Publication Date

1-1-2015

Abstract

Six new carbazole alkaloids, murrastanine-A (1), murrastinine-A, -B, -C (2-4), murrayatanine-A (5) and bismahanimboline (6), were isolated from the bark and leaves of Murraya koenigii (Linn.) Spreng along with 24 known carbazole alkaloids. The structure of these compounds were elucidated by extensive spectroscopic analysis. Murrastinine-C (4) and murrayatanine-A (5) exhibited cytotoxic activity against HL-60 and HeLa (CD50<20 μg/mL) via MTT assay.

Keywords

Carbazoles, Cytotoxicity, Murraya koenigii, MTT assay, Rutaceae

Divisions

CHEMISTRY

Publication Title

Tetrahedron

Volume

71

Issue

23

Publisher

Elsevier

This document is currently not available here.

Share

COinS