Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.

Authors

V.A. Yap
B.J. Loong
K.N. Ting
S.H.S. Loh
Kien Thai YongFollow
Yun Yee LowFollow
Toh Seok KamFollow
K.H. Lim

Document Type

Article

Publication Date

1-1-2015

Abstract

Hispidacine, an 8,4′-oxyneolignan featuring incorporation of an unusual 2-hydroxyethylamine moiety at C-7, and hispiloscine, a phenanthroindolizidine alkaloid, were isolated from the stem-bark and leaves of the Malaysian Ficus hispida Linn. Their structures were established by spectroscopic analysis. Hispidacine induced a moderate vasorelaxant activity in rat isolated aorta, while hispiloscine showed appreciable antiproliferative activities against MDA-MB-231, MCF-7, A549, HCT-116 and MRC-5 cell lines.

Keywords

Ficus hispida, Moraceae, Alkaloids, Neolignans, Phenanthroindolizidine, NMR, Antiproliferation, Vasorelaxation

Divisions

CHEMISTRY,InstituteofBiologicalSciences

Funders

MOHE Malaysia (FRGS/2/2013/SG01/UNIM/02/1 and HIR-005)

Publication Title

Phytochemistry

Volume

109

Publisher

Elsevier