Effects of silicate and carbonate substitution on the properties of hydroxyapatite prepared by aqueous co-precipitation method
Document Type
Article
Publication Date
1-1-2015
Abstract
This research was conducted to investigate the effects of silicate and carbonate substitutions in hydroxyapatite (HA) on phase retention, physical properties, and in vitro biological response. A wet chemical method was employed to synthesize silicate-substituted HA (Si-HA) and carbonate-substituted HA (CHA). It was shown that the presence of silicate and carbonate ions in the HA lattice increases the specific surface area and Ca/P molar ratio. In addition, the substitution also resulted in a reduction in the crystallinity of the HA powder and promoted better bioactivity of the sintered body. This was confirmed through in vitro cell culture experiment which revealed that the osteoblast cells adhered well on the surface of the ceramic and that ionic-substituted HA exhibited better cell performance than the control HA. (C) 2015 Elsevier Ltd. All rights reserved.
Keywords
Hydroxyapatite, Ionic-substituted hydroxyapatite, Characterization, In vitro evaluation, Cell response
Publication Title
Materials & Design
Volume
87
Publisher
Elsevier