Neolamarckines A and B, New Indole Alkaloids from Neolamarckia cadamba.

Document Type

Article

Publication Date

1-1-2011

Abstract

Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of inducible nitric oxide synthase (iNOS) dose dependently.

Keywords

neolamarckine, indole, Neolamarckia cadamba, Rubiaceae, inducible nitric oxide synthase activity

Divisions

CHEMISTRY

Publication Title

Chemical & Pharmaceutical Bulletin

Volume

59

Issue

2

Publisher

Pharmaceutical Society of Japan

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