Document Type
Article (Restricted)
Publication Date
1-1-2014
Abstract
Metal-based drugs with extensive clinical applications hold great promise for the development of cancer chemotherapeutic agents. In the last few decades, Schiff bases and their complexes have become well known for their extensive biological potential. In the present study, we examined the antiproliferative effect of a copper (II) complex on HT-29 colon cancer cells. The Cu(BrHAP)2 Schiff base compound demonstrated a potent tiproliferative effect in HT-29 cells, with an IC50 value of 2.87
Keywords
Schiff Base-Derived Copper (II) Complex, Potent Inducer of Apoptosis, Colon Cancer Cells, Intrinsic Pathway
Divisions
CHEMISTRY
Publication Title
Scientific World Journal
Publisher
Hindawi Publishing Corporation
Additional Information
Department of Biomedical Science, Faculty of Medicine, University of Malaya