Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors
Document Type
Article
Publication Date
1-1-2014
Abstract
Two new acridone alkaloids, chlorospermines A and B (1 and 2), were isolated from the stem bark of Glycosmis chlorosperma, together with the known atalaphyllidine (3) and acrifoline (4), by means of bioguided isolation using an in vitro enzyme assay against DYRK1A. Acrifoline (4) and to a lesser extent chlorospermine B (2) and atalaphyllidine (3) showed significant inhibiting activity on DYRK1A with IC50's of 0.075, 5.7, and 2.2 μM, respectively. Their selectivity profile was evaluated against a panel of various kinases, and molecular docking calculations provided structural details for the interaction between these compounds and DYRK1A. © 2014 The American Chemical Society and American Society of Pharmacognosy.
Keywords
acrifoline, atalaphyllidine, casein kinase I, chlorospermine a, chlorospermine b, cyclin dependent kinase, glycogen synthase kinase 3, plant extract, protein kinase inhibitor, unclassified drug
Divisions
fac_eng
Publication Title
Journal of Natural Products
Volume
77
Issue
5
Publisher
American Chemical Society