Document Type
Article
Publication Date
11-27-2013
Abstract
Resveratrol, a natural stilbene found in grapes and wines exhibits a wide range of pharmacological properties. Resveratrol is also known as a good chemopreventive agent for inhibiting carcinogenesis processes that target kinases, cyclooxygenases, ribonucleotide reductase and DNA polymerases. A total of 19 analogues with an amide moiety were synthesized and the cytotoxic effects of the analogues on a series of human cancer cell lines are reported. Three compounds 6d, 6i and 6n showed potent cytotoxicity against prostate cancer DU-145 (IC50 = 16.68 µM), colon cancer HT-29 (IC50 = 7.51 µM) and breast cancer MCF-7 (IC50 = 21.24 µM), respectively, which are comparable with vinblastine. The resveratrol analogues were synthesized using the Heck method.
Keywords
o-carboxamido stilbenes, amido stilbenes, Heck protocol, cytotoxic effects
Divisions
fac_med,CHEMISTRY
Funders
University of Malaya Postgraduate Research Grant (PPP) (PV090/2011A) and (PV050/2012A),Ministry of Higher Education (MOHE) Fundamental Research Grant Scheme (2010-0063-101-02),02), University of Malaya Research Grant (UMRG) (RP001/2012B),ScienceFund (SF018-2013)
Publication Title
International Journal of Molecular Sciences
Volume
14
Issue
12
Publisher
MDPI