Document Type
Article
Publication Date
1-1-2013
Abstract
This paper presents a theoretical development and critical analysis of the burst frequency equations for capillary valves on a microfluidic compact disc (CD) platform. This analysis includes background on passive capillary valves and the governing models/equations that have been developed to date. The implicit assumptions and limitations of these models are discussed. The fluid meniscus dynamics before bursting is broken up into a multi-stage model and a more accurate version of the burst frequency equation for the capillary valves is proposed. The modified equations are used to evaluate the effects of various CD design parameters such as the hydraulic diameter, the height to width aspect ratio, and the opening wedge angle of the channel on the burst pressure. © 2013 International Federation for Medical and Biological Engineering.
Keywords
Burst frequency equation, Centrifugal, Compact disc (CD), Microfluidics, Passive valve, Burst frequency, Centrifugal microfluidic platform, Hydraulic diameter, Modified equation, Multi-stage models, Passive valves, Theoretical development, Aspect ratio, Centrifugation, Compact disks, algorithm, article, compact disk, electronics, equipment, equipment design, hydrodynamics, theoretical model, Algorithms, Miniaturization, Models, Theoretical
Divisions
fac_eng
Publication Title
Medical and Biological Engineering and Computing
Volume
51
Issue
5
Additional Information
Thio, Tzer Hwai Gilbert Soroori, Salar Ibrahim, Fatimah Al-Faqheri, Wisam Soin, Norhayati Kulinsky, Lawrence Madou, Marc eng 1 R01 AI089541-01/AI/NIAID NIH HHS/ R01 AI089541/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2013/01/08 06:00 Med Biol Eng Comput. 2013 May;51(5):525-35. doi: 10.1007/s11517-012-1020-7. Epub 2013 Jan 6.