Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives
Document Type
Article
Publication Date
1-1-2013
Abstract
A library of some new fluorescent chromenopyrimidine derivatives has been synthesized by new approaches. Water-promoted and one-pot reaction can produce new dialkylylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl) phenols. These compounds can also be produced using domino reaction. Two parallel methods are compared. Novel N-alkyl-N-phenyl-5H-chromeno[2,3-d]-pyrimidin-4-amines and 4-alkoxy-5H-chromeno[2, 3-d]pyrimidines are synthesized by Lewis-acid catalyzed reactions. The fluorescence emission intensity of the four compounds from each of libraries after excitation in 290 nm is measured. Compound 2-(4,5-bis(N-methyl-N-phenylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol was isolated as a byproduct. The details of an interesting exchangeable intramolecular H- bonding of two of the new compounds are reported by X-ray analysis data. © 2013 American Chemical Society.
Keywords
chromenopyrimidine, fluorescent, green procedure, intramolecular H-bonding, Lewis acid, one-pot reaction
Divisions
CHEMISTRY
Publication Title
ACS Combinatorial Science
Volume
15
Issue
5
Publisher
American Chemical Society