Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011
Document Type
Article
Publication Date
1-1-2013
Abstract
From 1989 to 2011 in Kuala Lumpur, Malaysia, multiple genotypes from both respiratory syncytial virus (RSV) subgroups were found co-circulating each year. RSV-A subgroup predominated in 12 out of 17 years with the remaining years predominated by RSV-B subgroup. Local RSV strains exhibited temporal clustering with RSV strains reported in previous epidemiological studies. Every few years, the existing predominant genotype was replaced by a new genotype. The RSV-A genotypes GA2, GA5 and GA7 were replaced by NA1 and NA2, while BA became the predominant RSV-B genotype. A unique local cluster, BA12, was seen in 2009, and the recently-described ON1 genotype with 72-nt duplication emerged in 2011. Our findings will have important implications for future vaccine intervention.
Keywords
Human respiratory syncytial virus, Molecular epidemiology, Genotype, Malaysia
Divisions
fac_med
Publication Title
Infection, Genetics and Evolution
Volume
14
Publisher
Elsevier