Document Type
Article (Restricted)
Publication Date
1-1-2012
Abstract
We investigated 12 X-chromosomal short tandem repeat (STR) polymorphisms in 283 unrelated Malay individuals (160 males and 123 females) living in and around Kuala Lumpur using the Investigator Argus X-12 kit. Heterozygosity among the present 12 X-STRs showed a distribution of from 55.3 to 93.5 . The diversity values of the haplotypes constructed using four closely linked groups were all higher than 0.9865. A comparison of allelic frequency in each system and haplotype variation indicated that the nature of these X-STRs in the Malay population differed from that in East Asian, European, or African populations. Several microvariant alleles found in the Malay population were characterized and compared with known sequence data. The present data may be helpful in forensic casework such as personal identification and kinship testing in the Malay population in Malaysia.
Keywords
X chromosome STR Malay Argus X-12 Microvariant allele Closely linked group linkage groups powerful tool provides markers region
Divisions
GeneralDentalPracticeAndOralMaxillofacialImaging
Publication Title
International Journal of Legal Medicine
Volume
126
Issue
4
Additional Information
ISI Document Delivery No.: 962SN Times Cited: 0 Cited Reference Count: 20 Samejima, Michinaga Nakamura, Yasutaka Nambiar, Phrabhakaran Minaguchi, Kiyoshi Ministry of Education, Science, Sports and Culture22592345 The authors would like to thank Associate Professor Jeremy Williams, Tokyo Dental College, for his assistance with the English of this manuscript. This research was partially supported by the Ministry of Education, Science, Sports and Culture, Grant-in-Aid for Scientific Research (C) (22592345). Springer New york