Document Type
Article
Publication Date
1-1-2012
Abstract
Quorum sensing regulates bacterial virulence determinants, therefore making it an interesting target to attenuate pathogens. In this work, we screened edible, endemic plants in Malaysia for anti-quorum sensing properties. Extracts from Melicope lunu-ankenda (Gaertn.) T. G. Hartley, a Malay garden salad, inhibited response of Chromobacterium violaceum CV026 to N-hexanoylhomoserine lactone, thus interfering with violacein production; reduced bioluminescence expression of E. coli [pSB401], disrupted pyocyanin synthesis, swarming motility and expression of lecA::lux of Pseudomonas aeruginosa PAO1. Although the chemical nature of the anti-QS compounds from M. lunu-ankenda is currently unknown, this study proves that endemic Malaysian plants could serve as leads in the search for anti-quorum sensing compounds.
Keywords
Anti-quorum sensing, Bioluminescence, Leca::lux, Malaysian plants, N-acyl-l-homoserine lactones (ahl), Pseudomonas aeruginosa pao1, Pyocyanin, Virulence, Swarming motility
Divisions
InstituteofBiologicalSciences
Publication Title
Sensors
Volume
12
Issue
4
Publisher
MDPI
Additional Information
Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mails: etaly87@yahoo.com (L.Y.T.); yinwaifong@yahoo.com (W.-F.Y.)