Document Type
Article (Restricted)
Publication Date
1-1-2012
Abstract
The galloylated cyanogenic glucosides based on prunasin (1–7), gallotannins (8–14), ellagitannins (15–17), ellagic acid derivatives (18, 19) and gallic acid (20) isolated from the leaves of Phyllagathis rotundifolia (Melastomataceae) were investigated for their neuroprotective activity against hydrogen peroxide (H2O2)-induced oxidative damage in NG108-15 hybridoma cell line. Among these compounds, the gallotannins and ellagitannins exhibited remarkable neuroprotective activities against oxidative damage in vitro as compared to galloylated cyanogenic glucosides and ellagic acid derivatives in a dose-dependent manner. They could be explored further as potential natural neuroprotectors in various remedies of neurodegenerative diseases.
Keywords
Phyllagathis rotundifolia, Galloylated cyanogenic glucosides Hydrolysable tannins, Neuroprotective, NG108-15 hybridoma cell line, H2O2.
Divisions
CHEMISTRY,InstituteofBiologicalSciences
Publication Title
Fitoterapia
Volume
83
Issue
1
Publisher
Elsevier
Additional Information
Department of Chemistry, University of Malaya -------------doi:10.1016/j.fitote.2011.10.019