Document Type
Article
Publication Date
1-1-2012
Abstract
A new indole alkaloid; neonaucline (1), along with six known compounds-Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A-were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, (13)C-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopic methods especially 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. The excellent vasorelaxant activity on isolated rat aorta was observed for the alkaloids 1-3 after injection of each sample at 1 × 10-5 M.
Keywords
Ochreinauclea maingayii, Neonaucline, Nauledine, Cadamine, Rubiaceae, Alkaloid.
Divisions
CHEMISTRY
Publication Title
Molecules
Volume
17
Publisher
MDPI
Additional Information
Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia