Gelam honey inhibits lipopolysaccharide-induced endotoxemia in rats through the induction of heme oxygenase-1 and the inhibition of cytokines, nitric oxide, and high-mobility group protein B1

Authors

M. Kassim
K.M. Yusoff
G. Ong
S. Sekaran
M.Y.B.M. Yusof
M. MansorFollow

Document Type

Article (Restricted)

Publication Date

1-1-2012

Abstract

Malaysian Gelam honey has anti-inflammatory and antibacterial properties, a high antioxidant capacity, and free radical-scavenging activity. Lipopolysaccharide (LPS) stimulates immune cells to sequentially release early pro- and anti-inflammatory cytokines and induces the synthesis of several related enzymes. The aim of this study was to investigate the effect of the intravenous injection of honey in rats with LPS-induced endotoxemia. The results showed that after 4 h of treatment, honey reduced cytokine (tumor necrosis factor-α, interleukins 1β, and 10) and NO levels and increased heme oxygenase-1 levels. After 24 h, a decrease in cytokines and NO and an increase in HO-1 were seen in all groups, whereas a reduction in HMGB1 occurred only in the honey-treated groups. These results support the further examination of honey as a natural compound for the treatment of a wide range of inflammatory diseases. © 2012 Elsevier B.V. All rights reserved.

Keywords

Honey, Endotoxemia, Cytokines, High-mobility group box 1, Nitric oxide, Heme oxygenase-1

Divisions

fac_med

Publication Title

Fitoterapia

Volume

83

Issue

6