Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1
Document Type
Article
Publication Date
1-1-2012
Abstract
Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)-1. We found that the carriage of the human leukocyte antigen (HLA)-G minus 14-bp polymorphism, LILRB1 single nucleotide polymorphism rs1061680, and activating and inhibitory killer immunoglobulin-like receptors (KIRs) were different when data were compared between Caucasian, African Americans and Asian populations. However, carriage was similar when HIV-1 patients were compared with control donors, with the exception of the African American cohort.
Keywords
Human leukocyte antigen-G, killer immunoglobulin-like receptors, leukocyte immunoglobulin-like receptor subfamily B member
Divisions
fac_med
Publication Title
Tissue Antigens
Volume
79
Issue
5
Additional Information
Aghafar, M. Z. K. A. Witt, C. Kamarulzaman, A. Ismail, R. Lederman, M. M. Rodriguez, B. Senitzer, D. Lee, S. Price, P.