Development of an Alkaloid-Pyrone Annulation: Synthesis of Pleiomaltinine
Document Type
Article
Publication Date
1-1-2012
Abstract
Odd Couple: A method for the synthesis of alkaloid-pyrones using a novel pyrone annulation of β-carbolines and indoles with 3-siloxy-4-pyrones is reported. The approach has enabled synthesis of the unusual alkaloid-pyrone pleiomaltinine from the plant-derived indole-alkaloid pleiocarpamine (see Scheme; TBS= tert-butyldimethylsilyl). © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keywords
alkaloid, annulation, natural products, pyrones, quinone methides
Divisions
CHEMISTRY
Publication Title
Angewandte Chemie International Edition
Volume
51
Issue
37
Publisher
John Wiley & Sons
COinS