Antioxidant, cytotoxic activities, and structure-activity relationship of gallic acid-based indole derivatives
Document Type
Article
Publication Date
11-1-2011
Abstract
A new series of gallic hydrazones containing an indole moiety was synthesized through the reaction of gallic hydrazide and different indole carboxaldehydes. Their antioxidant activities were determined on DPPH radical scavenging and inhibition of lipid peroxidation. The in-vitro cytotoxic activities of the compounds were evaluated against HCT-116 (human colon cancer cell line) and MCF-7 (estrogen-dependent human breast cancer cell line) by the MTT method. An attempt to correlate the biological results with their structural characteristics has been done. A limited positive structure activity relationship was found between cytotoxic and antioxidant activities.
Keywords
Antioxidant activity, Cytotoxic activity, Gallic hydrazone, Indole
Divisions
CHEMISTRY
Publication Title
Archiv der Pharmazie / Chemistry in Life Sciences
Volume
344
Issue
11
Publisher
Wiley-VCH Verlag
Additional Information
Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA