Document Type
Article
Publication Date
1-1-2011
Abstract
The cytochrome oxidase subunit I (COXI) gene sequences of three recent (20072008) clinical Plasmodium knowlesi isolates from Klang Valley, peninsular Malaysia, were determined and compared with those of older (1960's) peninsular Malaysia, recent isolates from Sarawak (on Borneo Island), and an isolate from Thailand. Multiple alignment of the sequences showed that the three clinical isolates were more similar to the older peninsular Malaysia isolates than to those from Sarawak and Thailand. Phylogenetic tree based on the COXI sequences revealed three distinct clusters of P. knowlesi. The first cluster consisted of isolates from peninsular Malaysia, the second consisted of Sarawak isolates and the third composed of the Thailand isolate. The findings of this study highlight the usefulness of mitochondrial COXI gene as a suitable marker for phylogeographic studies of P. knowlesi.
Keywords
Parasitology (Medical Parasitology) Diagnostics (Molecular Diagnosis and Recombinant Antigens) Virology (Molecular Characterisation and Epidemiology)
Divisions
fac_med
Publication Title
Tropical Biomedicine
Volume
28
Issue
2
Publisher
Malaysian Society of Parasitology and Tropical Medicine
Additional Information
Fong, Mun Yik Lau, Yee-Ling Chin, Lit-Chien Al-Mekhlafi, Abdulsalam M. Q.