Document Type
Article
Publication Date
1-1-2011
Abstract
Mucuna pruriens has been used by native Nigerians as a prophylactic for snakebite. The protective effects of M. pruriens seed extract (MPE) were investigated against the pharmacological actions of N. sputatrix (Javan spitting cobra) venom in rats. The results showed that MPE-pretreatment protected against cardiorespiratory and, to a lesser extent, neuromuscular depressant effects of N. sputatrix venom. These may be explained at least in part by the neutralisation of the cobra venom toxins by anti-MPE antibodies elicited by the MPE pretreatment.
Keywords
Antivenom effects Immunology Mucuna pruriens seed Naja sputatrix venom
Divisions
fac_med
Publication Title
Indian Journal of Experimental Biology
Volume
49
Issue
4
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