Iron regulated outer membrane proteins (IROMPs) as potential targets against carbapenem-resistant Acinetobacter spp. isolated from a Medical Centre in Malaysia

Document Type

Article

Publication Date

4-1-2010

Abstract

In this study, a 29-kDa OMP has been identified to be the major outer membrane protein in A. baumannii / calcoaceticus and loss of this porin and overexpression of IROMPs have contributed to carbapenem resistance. Polyclonal antibodies raised against IROMPs may have a role in antimicrobial therapy in these isolates.

Keywords

Acinetobacter spp., imipenem, iron regulated outer membrane protein (IROMPs), meropenem, multiresistant, outer membrane protein (OMP), SDS-PAGE

Divisions

fac_med

Publication Title

Indian Journal of Medical Research

Volume

131

Publisher

Medknow Publications

Additional Information

Department of Medical Microbiology, Faculty of Medicine, University Malaya Kuala Lumpur, Malaysia.

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