Iron regulated outer membrane proteins (IROMPs) as potential targets against carbapenem-resistant Acinetobacter spp. isolated from a Medical Centre in Malaysia
Document Type
Article
Publication Date
4-1-2010
Abstract
In this study, a 29-kDa OMP has been identified to be the major outer membrane protein in A. baumannii / calcoaceticus and loss of this porin and overexpression of IROMPs have contributed to carbapenem resistance. Polyclonal antibodies raised against IROMPs may have a role in antimicrobial therapy in these isolates.
Keywords
Acinetobacter spp., imipenem, iron regulated outer membrane protein (IROMPs), meropenem, multiresistant, outer membrane protein (OMP), SDS-PAGE
Publication Title
Indian Journal of Medical Research
ISSN
0971-5916
Recommended Citation
Hwa, W.E.; Subramaniam, G.; Mansor, Marzida; Yan, O.S.; Anbazhagan, D.; and Devi, S.S., "Iron regulated outer membrane proteins (IROMPs) as potential targets against carbapenem-resistant Acinetobacter spp. isolated from a Medical Centre in Malaysia" (2010). Research Publications (2006 to 2010). 4706.
https://knova.um.edu.my/research_publications_2006_2010/4706
Divisions
fac_med
Volume
131
Publisher
Medknow Publications
Additional Information
Department of Medical Microbiology, Faculty of Medicine, University Malaya Kuala Lumpur, Malaysia.