Document Type
Article (Restricted)
Publication Date
1-1-2010
Abstract
Using Waldo's method in mice, we examined the immunohistochemical expression of Runx2 and alkaline phosphatase (ALP) appearing in dental pulp cells, especially in odontoblasts, just after receiving experimental orthodontic mechanical stress, using Waldo's method in mice. The examination results demonstrated that some dental root pulp cells, especially some odontoblasts, expressed the Runx2 and ALP in a comparatively short time after receiving the stress. The results suggest that the stress may cause odontoblast activity up-regulation.
Keywords
Orthodontics Dental pulp cells Mechanical stress Runx2 Alkaline phosphatase (ALP) Odontoblasts Up-regulation immunohistochemical observation tooth movement tension sides pulp expression
Divisions
OralPathologyOralMedicinePeriodontology
Publication Title
Journal of Hard Tissue Biology
Volume
19
Issue
1
Additional Information
ISI Document Delivery No.: 613LJ Times Cited: 4 Cited Reference Count: 13 Cited References: HAMERSKY PA, 1980, AM J ORTHOD DENTOFAC, V77, P368, DOI 10.1016/0002-9416(80)90103-7 Kawakami T, 2009, INT J MED BIOL FRONT, V15, P591 MASTAFA YA, 1991, AM J ORTHOD DENTOFAC, V99, P30 Matsuda H, 2009, J HARD TISSUE BIOL, V18, P181 Muraoka R, 2009, J HARD TISSUE BIOL, V18, P193 Nakano K, 2009, J HARD TISSUE BIOL, V18, P127 NIXON CE, 1993, J ENDODONT, V19, P13, DOI 10.1016/S0099-2399(06)81034-4 Shigehara Satoshi, 2006, Bull Tokyo Dent Coll, V47, P117, DOI 10.2209/tdcpublication.47.117 Villa PA, 2005, J ENDODONT, V31, P61, DOI 10.1097/01.DON.0000134212.20525.74 WALDO CM, 1953, J DENT RES, V32, P690 Watanabe T, 2009, J HARD TISSUE BIOL, V18, P175 Watanabe T, 2007, J HARD TISSUE BIOL, V16, P71, DOI 10.2485/jhtb.16.71 WATANABE T, 2008, EUR J MED RES, V13, P423 Nakano, Keisuke Muraoka, Rina Tomida, Mihoko Matsuura, Sachiko Okafuji, Norimasa Siar, Chong Huat Kawakami, Toshiyuki Japan Society for the Promotion of Science20592419 This study was supported in part by a Grant-in Aid for Scientific Research (C) (20592419) from the Japan Society for the Promotion of Science. The authors thank Professor DM Carlson, Matsumoto Dental University, for his critical reading of the manuscript. Journal hard tissue biology Minato ku