Document Type
Article
Publication Date
1-1-2010
Abstract
The role of paraoxonase 1 in cardiovascular disease complications in type 2 diabetes mellitus is not fully understood. We studied paraoxonase activity towards paraoxon in 188 non-diabetic and 140 diabetic subjects using general linear models and univariate analysis. Adjusting for age revealed a reduction in activity towards paraoxon was associated with a significant increase in risk (p=0.023) for cardiovascular disease complications in diabetic patients. Multivariate analysis of two plasma measures of paraoxonase activity using paraoxon and diazoxon also showed reduced paraoxonase activity towards paraoxon was associated with a significant increase in risk (p=0.045) for cardiovascular disease complications in diabetic patients. These analyses showed that a reduced paraoxonase activity towards paraoxon was associated with ethnicity. Based on multivariate analysis, subjects of Malay ethnic origin have significantly higher than expected activity (p=0.008, compared to Indians), towards paraoxon than subjects of Chinese origin who in turn had higher than expected paraoxonase activity (p=0.028, compared to Indians) Indian subjects.
Keywords
paraoxonase 1, cardiovascular disease, type 2 diabetes
Divisions
fac_med
Publication Title
Southeast Asian Journal of Tropical Medicine and Public Health
Volume
41
Issue
5
Publisher
Seameo Regional Tropical Medicine & Public Health
Additional Information
Correspondence: Rozaida Poh Yuen Ying, Department of Molecular Medicine, Faculty of Medicine, University of Malaya 50603, Kuala Lumpur, Malaysia. Tel: +603-79676611; Fax: +603-79676600 E-mail: rozaiday@um.edu.my