Unusual indole alkaloid-pyrrole, -pyrone, and -carbamic acid adducts from Alstonia angustifolia
Document Type
Article
Publication Date
1-1-2010
Abstract
Three unusual natural products, viz., alstopirocine, a macroline alkaloid incorporating a substituted pyrrole moiety, pleiomaltinine, an alkaloid-pyrone adduct, and pleiomalicine, an alkaloid-carbamic acid adduct, were isolated from the Malayan Alstonia angustifolia. The alkaloid moiety in alstopirocine was alstomicine while that in pleiomaltinine and pleiomalicine was pleiocarpamine. The structures were determined by spectroscopic methods and in the case of pleiomaltinine, confirmed by X-ray diffraction analysis. Possible biogenetic pathways to these unusual compounds are presented. (C) 2010 Elsevier Ltd. All rights reserved.
Keywords
Alkaloid-pyrrole, Alkaloid-pyrone, Alkaloid-carbamic acid, Alstonia
Publication Title
Tetrahedron
Volume
66
Issue
39
Publisher
Elsevier
Publisher Location
THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND